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MutPred-Indel is a standalone and web application developed to classify human non-frameshifting indels as pathogenic or benign. In addition, it predicts their impact on over 50 different protein properties and, thus, enables the inference of molecular mechanisms of pathogenicity.
The web server can be used for small-scale data sets (at most 100 variants). The webserver requires a modified FASTA format input, wherein each mutation is represented by wildtype and mutant protein sequences.
The standalone executable can be used for genome-scale data sets. As input, the MutPred-Indel software requires the output file from ANNOVAR's coding_change.pl program. To install and run MutPred-Indel, you will need about 16 GB of hard disk space and about 8 GB RAM. Click on the link below to download.
Before downloading: please read the MutPred-Indel license agreement.